Ga68Gallium 68

Gallium-68 is a widely used radioisotope in positron emission tomography (PET) and it has a half-life of 68 minutes. This isotope can be used to label different small molecules and peptides for diverse applications. The most popular applications are for prostate cancer imaging (68Ga-PSMA) and for neuroendocrine tumours (68Ga-peptides such as DOTA-TATE, DOTA-TOC and DOTA-NOC).

To produce Gallium 68,
we recommend this production route:

  • Recommended

    Target:

    Nirta® Liquid target

    The irradiation of enriched zinc solution takes place in the Nirta®  68Ga Conical liquid target. The production of 68Ga using a liquid target is a simple & cost- effective GMP solution similar to the 18F process.

    More about Nirta® liquid target

    Chemistry:

    Synthera® Extension, Synrhera® +

    The solution recovered from the target is purified on a Synthera® Extension with a two-step purification process (solid phase extraction) leading to [68Ga ]GaCl3. The labelling can then be performed using a cold kit or the  Synthera®+ .

    The Synthera®+ system employs an IFP™ disposable cassette system, where the labelling of the peptides (e.g DOTA-NOC, DOTA-TATE, DOTA-TOC, and PSMA-11) takes place.

    More about Synthera® Extension & Synthera® +

    Process under Patent EP15170854

  • Recommended

    Target:

    Solid target

    68Ga can also be obtained using a solid target. The process is more complicated.

    More about Nirta® solid target

    Chemistry:

    Dissolution module & Purification

    The irradiated target material can be purified and used for further labeling.

    Chemistry support only provided by IBA.

  • Alternative

    Target:

    Solid target

    68Ga can also be obtained using a solid target. The process is more complicated. IBA provides only the irradiation station equipment.

    More about Nirta® solid target

    Chemistry:

    Dissolution module & Purification

    The irradiated target material can be purified and used for further labelling.

    Chemistry support not provided by IBA.

  • Alternative

    Target:

    68Ge from generator

    The 68Ge produced by Cyclone® 30  is used for the manufacturing of  the  generator 68Ge/68Ga. The 68Ge is a  long half-life  isotope (270,95 days), the generator can be shipped around the world.

    More about Cyclone® 30 XP

    Chemistry:

    Synthera® Extension, Synthera® +

    The 68Ga from the generator is eluted with the help of the Synthera® Extension. The labelling can then be performed using a cold kit or the  Synthera®+ . The Synthera® system employs an IFP™ disposable cassette system, where the labelling of the peptides (e.g DOTA-NOC, DOTA-TATE, DOTA-TOC, and PSMA-11) takes place.

    More about Synthera® Extension & Synthera® +

Scientific publications