Fluorine-18 is the most widely used radioisotope in positron emission tomography (PET). Its applications are numerous in the field of Oncology, Cardiology and Neurology. The most common tracer of this radionuclide is glucose analog labelled compound: fluorodeoxyglucose (FDG).
Nirta® Liquid target
The Nirta® 18F conical liquid target enables the highest beam current while using the smallest amount of enriched water of the market.
Synthera® +
The Synthera® + is a fully automated synthesizer for labelling of your 18F compounds ( [18F]FDG,[18F]FPSMA-1007, [18F]NaF, [18F]FET; [18F]FLT, [18F]FMISO, [18F]FCH and many more). It offers multi-run of various different tracers in combination with the IFP™ Loader system and automatic ejection.
Nirta® Liquid target
The Nirta® 18F conical liquid target enables the highest beam current while using the smallest amount of enriched water of the market.
Synthera® +
The Synthera® + is a fully automated synthesizer for labelling of your 18F compounds ( [18F]FDG,[18F]FPSMA-1007, [18F]NaF, [18F]FET; [18F]FLT, [18F]FMISO, [18F]FCH and many more). It offers multi-run of various different tracers in combination with the IFP™ Loader system and automatic ejection.
Nirta® Liquid target
The Nirta® 18F conical liquid target enables the highest beam current while using the smallest amount of enriched water of the market.
Synthera® +
The Synthera® + is a fully automated synthesizer for purification and labelling of your 18F compounds ( [18F]FDG,[18F]FPSMA-1007, [18F]NaF, [18F]FET; [18F]FLT, [18F]FMISO, [18F]FCH and many more). It offers multi-run of various different tracers in combination with the IFP™ Loader system and automatic ejection.
Nirta® Liquid target
The Nirta® 18F conical liquid target enables the highest beam current while using the smallest amount of enriched water of the market.
Synthera® +
The Synthera® + is a fully automated synthesizer for purification and labelling of your 18F compounds ( [18F]FDG,[18F]FPSMA-1007, [18F]NaF, [18F]FET; [18F]FLT, [18F]FMISO, [18F]FCH and many more). It offers multi-run of various different tracers in combination with the IFP™ Loader system and automatic ejection.
In the present work we investigated the clinical utility of Al[18F]F-NOTAOctreotide (Al[18F]F-OC) in comparison to [68Ga]Ga-DOTA-TATE in patients diagnosed with neuroendocrine tumours. Our aim was to verify the recently published, promising results for Al[18F]FNOTA-Octreotide in the Latin-American population. Al[18F]F-NOTA-Octreotide provided excellent image quality, detected NET lesions with high sensitivity and represents a highly promising, clinical alternative to [68Ga]Ga-DOTA-TATE.
The α4β2 nicotinic acetylcholine receptor (nAChR) ligand 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine ([18F]nifene) has been synthesized in 10% decay-corrected radiochemical yield using the IBA Synthera® platform (IBA Cyclotron Solutions, Louvain-la-Neuve, Belgium) with an integrated fluidic processor (IFP). Boc-nitronifene served as the precursor, and 20% trifluoroacetic acid (TFA) was used to deprotect the Boc-group after radiolabeling. By omitting the solvent extraction step after radiolabeling, the process was simplified to a single step with no manual intervention. [18F]Nifene was obtained in decay-corrected radiochemical yields of 10 ± 2% (n = 20) and radiochemical purity >99%. Typical specific radioactivities of 2700–4865 mCi/μmole (100–180 GBq/μmol) were measured at the end of synthesis; total synthesis times were about 1 h 40 min.
R Catalan (1) G Quincoces (1) CHalezquer (1) M Ciordia (1) R Casanova (1) L Lopez-Sanchez (1) M Sanchez-Martinez (1) S Peña (1) J Richter (2) I Peñuelas (1) . Radiopharmaceutical Unit PET-GMP .Clínica Universidad Navarra.
Shinn Dee Yeoh, Uwe Ackermann, Henri Tochon-Danguy, John Sachinidis, Rachel Mulligan and Stan Poniger
Leandro Silva, Pablo Pace, Carlos Hormigo, Patricia Zubata, Natalia Leonardi, Marcela Zubillaga, Jorge Nicolini, Ricardo Caro, Guillermo Casale, Nathaniel C. Lim, Tyler E. Benedum
Bernard Lambert, Jean-Jacques Cavelier, Guillaume Gauron, Christophe Sauvage, Cécile Kech, Timothy Neal, David Caron, Anat Shirvan, Ilan Ziv
Alexander Schmitz & Richard Freifelder
A.G. Horti, M. Y. Kiselev, H.T. Ravert, R. L. Wahl, R.F. Dannals
Mori, Tetsuya, Arai, Ryo, Lambert, Bernard, Gameiro-Paris, Cristiana, Kosuga, Takeshi, Asai, Tatsuya, Fujibayashi, Yasuhisa, Okazawa, Hidehiko, Kiyono, Yasushi
Shinn Dee Yeoh, John I. Sachinidis, Henri Tochon-Danguy, Andrew M. Scott, Uwe Ackermann
Uwe Ackermann, Shinn Dee Yeoh, John I. Sachinidis, Stan S. Poniger, Andrew M. Scott and Henri J. Tochon‐Danguy
Koziorowski, Jacek; Fedorova, Olga; Stålmo, Kenneth
Alexander Schmitz, Richard Freifelder
Blykers, Anneleen, Vaneycken, Ilse, Xavier, Catarina, Everaert, Hendrik, Caveliers, Vicky
Alexander Schmitz, Richard Freifelder
A.J. Abrunhosa, F. Alves, I. Oxley, R. Boumon and C. Gameiro
Alexander Schmitz, Richard Freifelder
Gameiro C., Lambert B, SauvageC., Koziorowski J., Ilan Z, SchmitzA., Freifelder R., Ackermann U. and Tochon-Danguy H.J.
Vaneycken Ilse, Blykers Anneleen, Xavier Catarina, Caveliers Vicky
V. Kramer, M. Piel, C. Elgueta, S. Höhnemann, A. Amaral, M. Avila, J. Ribbec, E. Perez, R. Pruzzo, P. Chana, C. Juri, F. Rösch and H. Amaral
Mori, Tetsuya, Arai, Ryo, Lambert, Bernard, Gameiro-Paris, Cristiana, Kosuga, Takeshi, Asai, Tatsuya, Fujibayashi, Okazawa, Hidehiko, Kiyono, Yasushi
Vāvere, Amy L.1; Hu, Bao2; Neumann, Kiel D.3; DiMagno, Stephen G.2; and Snyder, Scott E.1 1 St. Jude Children’s Research Hospital, Department of Radiological Sciences, Memphis, TN USA 2 University of Nebraska – Lincoln, Department of Chemistry, Lincoln, NE USA 3 Ground Fluor Pharmaceuticals, Lincoln, NE USA
Christophe Sauvage1, Neva Lazarova1, David Goblet1, Marco Mueller2 1 IBA Chemin du Cyclotron, Louvain-La-Neuve, Belgium, 2 ABX Heinrich-Glaeser-Str. 10-14, Radeberg, Germany
Cristiana Gameiro, Ian Oxley, Antero Abrunhosa, Vasko Kramer, Maria Vosjan, Arnold Spaans
Yanick Lee, Derrick Gibbings and Jean N. DaSilva
Filip Kužel, David Goblet
V. Kramer, R. Fernandez, M. P. Sandoval, C. Gameiro, D. Goblet, M. Müller, R.Martin, A-M Zerges, C. Sandoval, H.Amaral,
Mark H. Dornan, Daniil Petrenyov, José-Mathieu Simard, Antonio Aliaga, Guoming Xiong, Julien Ghislain, Barry Bedell, Vincent Poitout and Jean N. DaSilva
Robert Hopewell, Karen Ross, Alexey Kostikov, Tharick A. Pascoal, Thais Alberti, Monica Lacatus‐Samoila, Jean‐Paul Soucy, Idriss Bennacef, Eliane Kobayashi, Min Su Kang, Pedro Rosa‐Neto, Gassan Massarweh
Gameiro1, Cristiana; Bormans2, Guy; Abrunhosa3, Antero; 4Luurtsema, G. and Elsinga4,Philip
1 IBA-Ion Beam applications SA/BE; 2 PET Center, University of Leuven/BE; 3 ICNAS, University of Coimbra/PT; 4 Medical Imaging Centre, University of Groningen/NL.
S. Braccini*, A. Ereditato, Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics (LHEP), University of Bern, Switzerland Paola Scampoli, Department of Physical Sciences, University Federico II, Napoli, Italy and Department of Radiation Oncology, University of Bern, Switzerland Konrade von Bremen, SWANtec AG, Bern, Switzerland
F. Devillet, J.-M. Geets, M. Ghyoot, E. Kral, O. Michaux, B. Nactergal, V. Nuttens, IBA RadioPharma Solutions, Louvain-la-Neuve, Belgium J. Courtyn, IBA Molecular Europe, Paris, France R. Mooij, L. Perk, BV Cyclotron VU, Vrije Universiteit, Amsterdam, The Netherlands
Courtyn, Jan; Devillet, Fabienne*; Geets, Jean-Michel; Ghyoot, Michel; Kral, Eric;Michaux, Olivier; Mooij, Roel; Nactergal, Benoit; Nuttens, Vincent; Perk, Lars
M.Leporis, P.Rajec, M.Reich, M.Štefečka, O.Szöllos, P.Kováč BIONT, Karloveska 63, 842 29 Bratislava, Slovakia
S. Chana, D. Cryera, A.H. Asada,b, R.I. Pricea,c a Department of Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Western Australia b Imaging & Applied Physics, Curtin University, Western Australia c School of Physics, University of Western Australia, Western Australia
Faisal Alrumayan, F. Oberdorferb, Q. Akkam, J. Schneider, S. Alyanbawi and I. Al-Jammaz
M. Kiselev, B. Lambert, Vernal Richards, W.Skarupa, M. Wardach, J. Zehner, S. Ermolaev, B. Zhuikov
Samy Bertrand, Jean-Michel Geets, Benoit Nactergal, Fabienne Devillet, Eric Kral, Sebastien de Neuter, Jozef Comor, Francisco Alves
Thien Dinh; Stan Poniger, Harris Panopoulos, Henri Tochon-Danguy, Andrew Scott
HUS Helsinki University Hospital, Medical Imaging Center, Cyclotron Unit
Michal Košťál a,∗, Evžen Losa a, Martin Schulc a, Jan Šimon a, Zdeněk Matěj b, Michal Antoš c, Šimon Vadják c, Martin Cuhra c, František Cvachovec d, Filip Mravec b, Filip Brijar a,Tomáš Czakoj a, Vojtěch Rypar a
a Research Centre Rez, b Masaryk University, c UJV Rez, d University of Defence
N. Emmanuel, D. Goblet, G. Decoux, V. Kramer, F. Valla, J. Agudelo